Targeting LDL-C treatment: The good, the bad, and the rated X

Introduction by Richard Hellman, MD, FACP, FACE In this excellent case study, the authors show the importance of looking deeper than just the lipid numbers initially returned from the laboratory.  This case highlights the pitfalls for the unwary physician who fails to use all the available clinical information when making a decision as to what […]

Patient Safety, Insulin Pumps, and Cognitive Dysfunction

Earlier today, I consulted on a patient in the hospital who was there because of recurrent hypoglycemia. It was an interesting problem. The patient was an 85-year-old man, with a 39-year history of insulin dependent diabetes, who had been on an external insulin pump for twenty-five years. During the past two years, he had been […]

Propylthiouracil (PTU) Hepatotoxicity and Graves’ Disease Therapy

Scott A. Rivkees, M.D. Yale Pediatric Thyroid Center Yale University School of Medicine New Haven, CT Donald R. Mattison MD, CAPT, Obstetric and Pediatric Pharmacology Branch Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD David S. Cooper, M.D. Division of Endocrinology and Metabolism The Johns Hopkins […]

Safety in the ICU – Is Bedside Glucose Testing Safe For Our Patients?

In my recent editorial on the NICE-SUGAR study, I raised the question as to whether the methods commonly used to measure glucose levels at the bedside may be the source of error that may pose a hazard to the patient. A very important article by Scott, Bruns, Boyd, and Sacks, just published on-line in Clinical […]


The U.S. Department of Health and Human Services has issued a final rule for Patient Safety Organizations (PSOs). The rule becomes effective on Jan. 19, 2009. It provides final requirements and procedures for PSOs, new entities, with which clinicians and health care providers can work to collect, aggregate and analyze data — within a legally […]

Patient Safety in Diabetes Care and Intensive Glycemic Therapy

In June 2008, the results of both the ADVANCE and ACCORD studies became public. The results were published in the New England Journal of Medicine (NEJM) on June 12, 2008, presented at the American Diabetes Association (ADA) meeting, and widely discussed in the public media as well. The two trials, ADVANCE and ACCORD, are clearly […]

Insulin Pens and Safety

The Institute for Safe Medication Practices (ISMP) released an article recently that highlighted potential safety problems that are being seen in hospitals when they switch the delivery of insulin subcutaneously from insulin that is drawn from multiple-dose vials to insulin pens. The details of the ISMP Medication Safety Alert were included in an FDA Patient […]